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RLL's Story begins...
with a molecule essential to the health of all living cells. That molecule is called Proliferating Cell Nuclear Antigen or PCNA.
The PCNA Story
To promote cell division, PCNA acts as a circular clamp, surrounding the DNA molecule, guiding the replication process.
PCNA is a critical ‘hub’ to many vital cellular processes: Over 200 key molecules bind to the PCNA clamp and are essential for normal cellular repair and replication.

How AOH1996 Works
In 1998, Dr. Malkas’ team discovered an isoform of PCNA (“ca-PCNA”) that is uniquely present and stable only in cancer cells.
RLL’s revolutionary therapeutic drug, AOH1996, binds specifically to the unique structure of ca-PCNA, inhibiting cancer cell replication and leading to cancer cell death via apoptosis.
Preclinical data has established that ca-PCNA acts on cancerous cells while having minimal to no effect on the replication of healthy cells.​

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